NIPP-1, His•Tag, Recombinant,Bovine Thymus, E. coli
Nuclear Inhibitor of Protein Phosphatase-1
Bovine NIPP-1 fused to a His•Tag. Recombinant protein, sequenced and expressed in E. coli. Specific and very potent inhibitor of protein phosphatase 1 (PP1; Ki = 1-10 pM). It can be used to distinguish PP1 from other major serine/threonine protein phosphatases including PP2A, PP2B, and PP2C. Also an ideal substrate for protein kinase A and casein kinase II. Thought to be involved in the targeting of PP1 to RNA-associated substrates and may also be involved in the dephosphorylation of transcription factors like CREB and the tumor suppressor Rb.
ordering number | size | quantity | price |
04-NIPP1-5ug | 5μg | 300,00 € |
Product information:
form | liquid |
formultion | In 500 mM NaCl,pH 7.5,500 µM benzamidine, 20 mM Tris, 500 µM PMSF, 5 µM leupeptin |
primary target | PP1 |
Primary Target Ki | 1-10 pM |
Avoid freeze/thaw | yes |
Purity | ≥92% by SDS-PAGE |
Store and ship information:
storage | -20°C |
ship | dry ice only standard handling |
Central Fragment of NIPP-1 (residues 143-224), His•Tag, Recombinant,Bovine Thymus, E. coli
EFFICIENCY – Ic50 = 0,2 μM !!!
MORE STABLE IN HIGH TEMPERATURES !!!
Inhibitor of Protein Phosphatase-1
Fragment of NIPP-1 (residues 143-224) fused to a His•Tag. Recombinant protein, sequenced and expressed in E. coli. Specific and very potent inhibitor of protein phosphatase 1. It can be used to distinguish PP1 from other major serine/threonine protein phosphatases including PP2A, PP2B, and PP2C. Also an ideal substrate for protein kinase A and casein kinase II. Thought to be involved in the targeting of PP1 to RNA-associated substrates and may also be involved in the dephosphorylation of transcription factors like CREB and the tumor suppressor Rb.
ordering number | size | quantity | price |
04-FRNIPP1-5ug | 5μg | 500,00 € |
Product information:
form | liquid |
formultion | In 500 mM NaCl,pH 7.5,500 µM benzamidine, 20 mM Tris, 500 µM PMSF, 5 µM leupeptin |
primary target | PP1 |
Avoid freeze/thaw | yes |
Purity | ≥92% by SDS-PAGE |
Store and ship information:
storage | -20°C |
ship | dry ice only standard handling |